| Title: Alpha Lipoic Acid and Other Antioxidants May Prevent Cell Death by Chelating Metals Author(s): Persson HL, Svensson AI, Brunk UT. Source: Redox Rep. 2001;6(5):327-34. Content: Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Summary: Alpha Lipoic Acid and other antioxidants may prevent cell death by chelating metals. Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden. lennart.persson@lio.se Alpha-lipoic acid (LA) and its corresponding derivative, alpha-lipoamide (LM), have been described as antioxidants, but the mechanisms of their putative antioxidant effects remain largely uncharacterised. The vicinal thiols present in the reduced forms of these compounds suggest that they might possess metal chelating properties. We have shown previously that cell death caused by oxidants may be initiated by lysosomal rupture and that this latter event may involve intralysosomal iron which catalyzes Fenton-type chemistry and resultant peroxidative damage to lysosomal membranes. Here, using cultured J774 cells as a model, we show that both LA and LM stabilize lysosomes against oxidative stress, probably by chelating intralysosomal iron and, consequently, preventing intralysosomal Fenton reactions. In preventing oxidant-mediated apoptosis, LM is significantly more effective than LA, as would be expected from their differing capacities to enter cells and concentrate within the acidic lysosomal compartment. As previously reported, the powerful iron-chelator, desferrioxamine (Des) (which also locates within the lysosomal compartment), also provides protection against oxidant-mediated cell death. Interestingly, although Des enhances the partial protection afforded by LA, it confers no additional protection when added with LM. Therefore, the antioxidant actions of LA and LM may arise from intralysosomal iron chelation, with LM being more effective in this regard. More/Expanded Article Information: [ click here ] Click Here To View An Alpha Lipoic Acid Supplier Website! |
|
This site is a service of CCWEBGROUP that provides and reports interesting information that is available to the general public. CCWEBGROUP is not in any way involved in performing the scientific studies, completing the analyses, nor evaluating the results.
Many studies reported herein have been performed on laboratory animals and not on humans. While some results of animal trials are later found to be similar in human trials, we have no way of knowing whether or not this will be the case. This information is not presented as medical advice and no conclusions regarding the effectiveness or lack of such should be drawn from this information. As with any information that pertains to your health, please discuss your questions and/or conclusions with your physician or healthcare provider. |
|
copyright © 2005 :: ccwebgroup :: all rights reserved
|