| Title: Lipoic Acid Therapy for Chronic Diseases Associated with Oxidative Stress Author(s): Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Source: Curr Med Chem. 2004 May;11(9):1135-46. Content: Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Summary: Study looks at efficacy of using alpha lipoic acid as a treatment for certain pathophysiologies of some chronic diseases. Dept. of Biochemistry and Biophysics and the Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, Oregon 97331, USA. alpha-Lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes. Aside from its enzymatic role, in vitro and in vivo studies suggest that LA also acts as a powerful micronutrient with diverse pharmacologic and antioxidant properties. Pharmacologically, LA improves glycemic control, polyneuropathies associated with diabetes mellitus, and effectively mitigates toxicities associated with heavy metal poisoning. As an antioxidant, LA directly terminates free radicals, chelates transition metal ions (e.g. iron and copper), increases cytosolic glutathione and vitamin C levels and prevents toxicities associated with their loss. These diverse actions suggest that LA acts by multiple mechanisms both physiologically and pharmacologically, many of which are only now being explored. Herein, we review the known biochemical properties of LA with particular reference to how LA may be an effective agent to ameliorate certain pathophysiologies of many chronic diseases. More/Expanded Article Information: [ click here ] Click Here To View An Alpha Lipoic Acid Supplier Website! |
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